What's Actually within the COVID-19 Vaccines?

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What's Actually within the COVID-19 Vaccines?


Jan Jekielek, senior editor with The Epoch Times and host of “American Thought Leaders,” spoke with microbiologist Kevin McKernan — a former researcher and workforce chief for the MIT Human Genome venture1 — about DNA contamination in COVID-19 pictures.2

In a preprint research McKernan and colleagues assessed the nucleic acid composition of 4 expired vials of the Moderna and Pfizer mRNA pictures. “DNA contamination that exceeds the European Medicines Agency (EMA) 330ng/mg requirement and the FDAs 10ng/dose necessities” was discovered.3

So, along with the spike protein and mRNA in COVID-19 pictures, McKernan’s workforce additionally found simian virus 40 (SV40) promoters that, for many years, have been suspected of inflicting most cancers in people, together with mesotheliomas, lymphomas and cancers of the mind and bone.4 The media have been fast to “reality test” the discovering, with the AP publishing a rebuttal titled, “No, ‘Monkey Virus DNA’ Was Not Found in COVID Vaccines.’”5

Speaking with Jekielek, McKernan took concern with the AP’s reality test article, noting their paper “by no means mentioned that all the virus was current within the vaccines. We mentioned that the promoter and the enhancer and the origin was in there, together with the polyA sign. It appears as if the AP has erected a strawman argument the place they’re making an attempt to debunk one thing that was by no means mentioned.”6

Could DNA Contamination in COVID Shots Cause Cancer?

The AP and different media shops additionally downplayed the notion that DNA contamination in COVID-19 injections might contribute to most cancers. “They are attempting to make claims that this isn’t cancer-causing,” McKernan says, however “there are limits on how a lot DNA may be in a vaccine exactly due to the priority over DNA integration.”7

Such pointers have been primarily based on analysis by the U.S. Food and Drug Administration’s molecular biologist Keith Peden,8 however when he evaluated how a lot DNA might “safely” exist in vaccines, he didn’t contemplate lipid nanoparticles (LNPs) and different components that might improve how a lot DNA might enter a cell. McKernan explains:9

“Here are two extra issues happening that imply the DNA in these vaccines is extra prone to get to the nucleus and combine into the genome than the data that they had at the moment. When they got here to these laws, they have been assuming the earlier DNA within the pictures have been host cell DNA, like possibly you grew the vaccine in some sort of monkey kidney cell.

As a results of this, there’s background monkey DNA, or background human DNA, as a result of no matter host cell line they use. We have one thing very completely different happening right here. We have a well known promoter that is utilized in gene remedy that is contained in the vaccines that is getting injected by an LNP that makes it very efficient at transecting cells. Then it has a sign in there that drives that DNA into the nucleus.

I do not assume Keith Peden had anticipated that when he got here up with these 10 nanogram limits of DNA. I’d say the decision remains to be out as as to whether or not they are often cancer-causing, however the threat is definitely elevated from what the FDA’s pointers have been constructed off of.”

How SV40 Promoters in COVID Shots Could Drive Disease

McKernan explains that in lots of instances, when tumors are sequenced, they’re discovered to include sequences from SV40 and different viruses, which may combine into your genome, inflicting disruptions and instability that may set off the cell line to develop uncontrolled.10

In the case of COVID-19 pictures, he says, “The concern is that if this DNA integrates the genome, one portion of the SSV40 sequence is an SV40 promoter, a really sturdy promoter, which implies it drives transcription wherever it lands within the genome.

If this occurs to drop itself in entrance of a proto-oncogene [a gene that has the potential to cause cancer] and drives numerous expression off of a gene that is recognized, for those who hyper-express it and switch the cell cancerous, then we have now a priority that DNA is in reality doing that.”11

But not solely do COVID-19 pictures include SV40 promoters, in addition they include a 72 base pair insertion that makes the promoter rather more aggressive and in addition drives the sequence into the nucleus of the cell. “And they’re proper subsequent to one another,” McKernan says. “If this DNA strikes into the nucleus and it drags a promoter with it, and that integrates in entrance of a gene, it could actually disrupt gene regulation and probably result in the oncogenesis.”12

At the identical time, a Pfizer trial confirmed that the pictures might induce lymphocytopenia and neutropenia, or low concentrations of white blood cells. This might additional permit for cancerous adjustments to proliferate. “After vaccination, sufferers have decrease white blood cells, which you should filter out cells which are misbehaving, like most cancers cells,” McKernan provides.13

He’s additionally seen analysis exhibiting that the spike protein from COVID-19 pictures can enter the nucleus and disrupt regulation of p53 and BRCA1 genes:14

“People are in all probability acquainted with BRCA1 due to breast most cancers genes, however p53 can also be one other guardian of the genome. These are genes that clear up genomes which have been damaged or have integration occasions …

If you have got all three of these probably elevated integration dangers occurring, with white blood cell discount and spike protein inhibiting the genes that should clear up the sort of drawback, the mix of these issues might definitely be tied to the rise in most cancers that we’re at the moment seeing.”

COVID Shots’ Lipid Nanoparticles Could Also Be Toxic

Another regarding compound in COVID-19 pictures are the lipid nanoparticles, or LPNs. Because pure mRNA is well damaged down, this implies the gene remedy wants a particular supply system to make it to the physique’s cells. Moderna and Pfizer used lipid nanoparticles that include polyethylene glycol (PEG)15 for this goal.

The mRNA is wrapped in lipid nanoparticles (LNPs) that carry it to your cells, and the LNPs are “PEGylated” — that’s, chemically connected to PEG molecules to extend stability.16 In their company prospectus17 launched in 2018 on the time of their inventory market launch, Moderna acknowledged that their LNPs carried dangers.18 Among them, Moderna said:

  • “Most of our investigational medicines are formulated and administered in an LNP which can result in systemic unwanted effects associated to the parts of the LNP which can not have ever been examined in people.”19
  • “While we have now continued to optimize our LNPs, there may be no assurance that our LNPs is not going to have undesired results. Our LNPs might contribute, in entire or partly, to a number of of the next: immune reactions, infusion reactions, complement reactions, opsonation reactions, antibody reactions together with IgA, IgM, IgE or IgG or some mixture thereof, or reactions to the PEG from some lipids or PEG in any other case related to the LNP.”20

Meanwhile, the shot trials didn’t embody a management to indicate what occurs for those who simply expose folks to LNPs with out mRNA. McKernan says:21

“What occurs to folks in that case? We do not know the reply to that … a 12 months from now, there will probably be extra of a scientific consensus that spike protein was a nasty concept, and that possibly we must always change this to a unique protein or possibly we must always use this platform to hit RSV [respiratory syncytial virus] or flu. If we do not know the toxicity of the LNPs alone, that is likely to be simply as harmful of an method.

We actually do want to grasp if this transfection is an effective option to fend off a respiratory virus. Many folks have argued that this can be a horrible option to thwart off a respiratory virus since you’re constructing immunity within the mistaken compartment of the physique.

You actually need immunity within the nasal mucosa, and you are not going to get very efficient nasal mucosa immunity by injection. You tackle all of those injection dangers the place you are sending LNPs by all the physique and it is not very focused.”

What Happens if Shot Particles Enter the Ovaries?

There are considerations that shot particles are touring all through the physique with unknown results. Pfizer’s biodistribution research, which was used to find out the place the injected substances go within the physique, confirmed the spike protein from the pictures collected in “fairly excessive concentrations” within the ovaries.22

A Japanese biodistribution research for Pfizer’s jab additionally discovered that vaccine particles transfer from the injection web site to the blood, after which circulating spike proteins are free to journey all through the physique, together with to the ovaries, liver, neurological tissues and different organs.23 According to McKernan:24

“We know from the biodistribution research that a few of these LNPs are attending to the ovaries, in order that’s an enormous concern. If 1% of those LNPs get to the ovaries, there’s 40 billion in every shot, we’re getting all the way down to 400 million that go to the ovaries. Now you are beginning to actually concern your self.

If there’s solely 300,000 oocytes in every feminine, and there are 400 million LNPs down there, these numbers are worrisome. What are we doing to the germline sooner or later era?”

Already, a research printed in Obstetrics & Gynecology — and funded by the National Institute of Child Health and Human Development (NICHD) and the National Institutes of Health (NIH) Office of Research on Women’s Health — confirmed an affiliation between menstrual cycle size and COVID-19 pictures.25

The implication is that the pictures might be having an impact on fertility. As the Obstetrics & Gynecology researchers famous, “Menstrual cyclicity is an overt signal of well being and fertility.”26

‘There Is Residual DNA in Both Shots’

As for why the SV40 promoter and enhancer is in COVID-19 pictures within the first place, it’s associated to the plasmid progress medium, which is E. coli. McKernan explains:27

“It’s [SV40 promoter] a standard device used within the biotech business to drive very aggressive expression of a gene. In this case, Pfizer has it in entrance of a neomycin resistance gene, which drives resistance for neomycin. The motive they need it there may be in order that they’ll develop this plasmid in E. coli.

E. coli doubles each half-hour, so you possibly can develop E. coli in a single day and get gobs of this DNA. You then should purify it from E. coli to make RNA out of it.

There is a few threat that for those who do not totally purify it from E. coli, you possibly can depart behind what’s referred to as endotoxin or lipopolysaccharides, often abbreviated as LPS. This is an extra threat that Pfizer took on. Moderna’s doing a really related factor, though they do not have SV40 in there. They are utilizing E. coli to amplify their plasmid DNA, and it comes with a few of this threat.

What we do know is there may be residual DNA in each pictures, and this DNA is both proper above the regulatory restrict or tenfold larger … When RNA to DNA ratios, it is even worse. The precise consequence is that there’s extra like a 17- to 80-fold hole from what’s required within the laws, as finest we will inform.”

According to McKernan, Pfizer additionally used two completely different instruments to measure RNA versus DNA. This allowed them to “prepare dinner the books,” inflating the quantity of RNA and miserable the quantity of DNA so “they’ll squeak by these regulatory necessities with out anybody actually understanding what is going on on.”28 Further, Pfizer didn’t disclose its SV40 data to the European Medicines Agency, which McKernan believes was intentional:29

“They did that as a result of they know the SV40 area is a really controversial base in its historical past within the vaccine subject. The polio vaccines have been contaminated with the total virus, not simply these little parts, however the full virus.

The full virus has over 5,000 bases. The parts we have now are about 466 bases of the virus, however they’re arguably essentially the most practical elements of the virus’s genome for replicating and for gene expression. The undeniable fact that they hid that that is in there from the EMA is a priority.”

While McKernan and colleagues proceed to unfold the phrase about SV40 promotor and parts in COVID-19 pictures, the media continues to attempt to discredit their findings. McKernan factors out once more that they by no means said the SV40 virus is within the pictures — however that doesn’t make their research any much less worrisome:30

“We mentioned there was an SV40 promoter and a number of the parts. We have been very clear about that, however it rapidly received related to, ‘These guys are claiming there’s something there that isn’t there.’ Then everybody missed the purpose that there are parts of SV40 which are really fairly practical that we should be involved about.

They are in these vaccines as a result of they have been studied as being gene remedy instruments … They are maybe not as horrifying as what occurred within the polio vaccine, which some folks have attributed to inflicting some cancers previously. It’s nonetheless an issue in that subject, however there’s nonetheless issues that we have to learn about.

… There does appear to be an inclination for them [media] to both erect a strawman, or flood the zone with alternate data, in order that a median particular person is simply confused on what to consider, as a result of there is a combination of messages coming by the media that should drown out the actual sign.”

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