High or extended doses of any of those behaviors or substances aren’t sustainable or wholesome (spend an excessive amount of time in chilly water, and also you’re gonna get hypothermia). But briefly bursts, the little little bit of irritation that these stressors trigger is simply sufficient to knock you out of comfy homeostasis and activate quite a lot of mobile mechanisms and signaling pathways that promote stress resilience, restore mobile injury (by way of processes like autophagy), restore DNA, fight oxidative stress, produce new mitochondria, scale back irritation, help elimination of poisons, enhance blood sugar regulation, scale back threat of most cancers, and extra, explains Rountree.