Study opens new therapeutic avenues for remedy of rheumatoid arthritis

A analysis group, led by Professor Sung Ho Park within the Department of Biological Sciences at UNIST introduced the outcomes of a research on osteoblasts that injury joint bones in sufferers with rheumatoid arthritis.

In this research, the analysis group studied the potential for a remedy technique focusing on mechanisms associated to the differentiation strategy of osteoblasts that soften bones by enzyme reactions. First, it was confirmed {that a} superinhancer is fashioned close to the NFATC1 gene, which is understood to be an vital issue within the formation of osteoblasts, and it’s fashioned solely in osteoblasts.

In addition, it was confirmed that an enhancer RNA, a sort of non-encrypted RNA, is fashioned within the NFATC1 superinhand throughout osteoblastic cell formation.

Non-encrypted RNA doesn’t encode proteins, however performs an vital function in regulating gene expression. In explicit, as a result of specificity of the molecular sequence, it may be simply focused for remedy. In truth, we noticed that interfering with NFATC1 superinhancer RNA inhibits the formation of osteoblasts collectively.

Through this research, it has been confirmed that NFATC1 super-in-hander RNA, which is fashioned throughout osteoblast differentiation, can be utilized as a remedy goal.

“Our research is the primary to determine SEs and SE-eRNAs in human osteoclasts and offers a greater understanding of human osteoclast biology, thereby opening new therapeutic avenues for human pathological bone destruction,” famous the analysis group.

The findings of this analysis have been made obtainable in December 2022, forward of its publication within the journal, Cellular and Molecular Immunology. This research has been supported by the National Research Foundation of Korea (NRF) grants, funded by the Ministry of Science and ICT (MSIT).