Reversing Endothelial Damage – BionicOldGuy

The endothelium is the innermost layer of blood vessels, which might change into broken as we grow old, an vital facet of heart problems. I found the very important function of the endothelium after I found that I’ve hypertension if it’s not managed by metoprolol (a drugs I’m on to forestall coronary heart arrhythmias, which have been a facet impact of my needing a coronary heart valve substitute). The blood stress incident and what I subsequently discovered from it’s mentioned right here. My most vital takeaway was to ensure I’ve plenty of nitrates in my weight-reduction plan, from meals like beets and arugula. That has been working properly for protecting blood stress regular. But that’s serving to to maintain my blood vessels dilating usually, regardless of age-related injury to the endothelium. As I discussed on the finish of that earlier publish, I’d wish to study tips on how to scale back injury to the endothelium.

It seems that is attainable, and that is mentioned within the newest video on Dr. Greger’s nutritionfacts web site. The secret is the function of endothelial progenitor cells, which assist with the well being of the endothelium. In the video an enchanting examine is described that demonstrates this. Peripheral artery illness is a kind of heart problems the impacts blood vessels just like the legs, in an identical method to how the coronary arteries are broken in coronary artery illness. The blood vessels will be so badly broken that victims are severely restricted in train capability, like solely with the ability to stroll for a minute or much less. In addition, necessity for amputation is usually a main consequence of peripheral artery illness. The researchers break up contributors into a bunch that acquired bone marrow transplants, and a management group that acquired solely an injection of their very own blood. The group with bone marrow transplants had considerably improved train time, versus no enchancment within the management. Also, within the management group, throughout follow-up over the following months, 14% required amputations over the following months versus none within the handled group. The improved arterial operate within the handled group is said to enhanced impact of endothelial progenitor cells [2].

So Dr. Greger now examined how can we increase endothelial progenitor cells by way of life means. Two very important components usually are not smoking (and avoiding publicity to secondhand smoke), and train. For weight-reduction plan, vital components are lowering saturated fats consumption, consuming a whole-food plant-based weight-reduction plan, and particularly consuming berries, onions, and ingesting inexperienced tea. I’m already checking all of the packing containers on this record besides the final two, so I intend to spice up onion consumption and check out inexperienced tea. The endothelium of my arteries most likely already appears to be like just like the “60+” within the image above. It’s thrilling to assume it’s attainable to reverse this and have successfully youthful arteries.

References

1. Sharma, S, et al, “Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate Safety and Therapeutic Efficacy of Angiogenesis Induced by Intraarterial Autologous Bone Marrow–Derived Stem Cells in Patients with Severe Peripheral Arterial Disease”, Journal of Vascular and Interventional Radiology, 2021. on-line right here
2. Teraa, M, et al, “Effect of repetitive intra-arterial infusion of bone marrow mononuclear cells in patients with no-option limb ischemia: the randomized, double-blind, placebo-controlled Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-arterial Supplementation”, Circulation, 2015. on-line right here.