I’ve been getting a number of emails a couple of new Xyngular product referred to as GLP-X. As the corporate web site says, ‘GLP-X is a premium supplement formula crafted from naturally sourced ingredients clinically studied to increase GLP-1 production.* (note asterisk that leads to disclaimer that none of these claims have been evaluated by the FDA) It isn’t nearly managing weight—it’s about elevating your outcomes.’
As a registered dietitian, I’m all the time concerned about taking a more in-depth have a look at these types of corporations and their dietary supplements, as a result of all too typically, I discover that they sidestep the reality, and the analysis, within the curiosity of creating gross sales.
This GLP-X evaluation examines the claims that Xyngular and its salespeople are making about this product, what GLP-1 is, and if we are able to actually ‘hack’ it with weight loss program and dietary supplements to imitate the motion of GLP-1 agonists like Ozempic.
What is GLP-1?
GLP-1, or glucagon-like peptide-1, is a peptide hormone that’s produced within the gut. Its job is to stimulate insulin (which brings glucose into cells, and is why GLP-1 medication have been initially permitted as medicines for diabetes), and inhibit glucagon (glucagon will increase blood sugar and fatty acids within the blood when meals isn’t current).
GLP-1 additionally slows down gastrointestinal motility, which makes us really feel fuller for longer. Hence, weight reduction (and certain, negative effects like vomiting for some people who find themselves on GLP-1 agonist meds).
How do GLP-1 agonists like Ozempic work?
I wrote about Ozempic and different GLP-1 agonists for weight reduction right here
We all have GLP-1 receptors in our physique. GLP-1 agonists are analog variations of our personal GLP-1 (related, however not precisely the identical), and so they work by binding to and activating our physique’s GLP-1 receptors.
When this occurs, we see the identical results as those I described above: elevated insulin and decreased glucagon, and slowed motility with ensuing fullness.
GLP-1 agonists have confirmed to be extraordinarily secure and efficient for weight reduction, however predictably, there are folks and corporations desirous to make their very own buck by convincing others that ‘Big Pharma’ is the enemy and that ‘natural’ GLP-1 dietary supplements are so a lot better than precise treatment.
Check out this submit about Xyngular GLP-X:
The selling of Big Pharma conspiracy theories whereas spouting the Appeal to Nature fallacy (pure is healthier! OMG SYNTHETIC MEDICATION!) is a basic gross sales tactic that’s sadly turning into extra widespread, particularly amongst multi-level advertising and marketing salespeople. It’s fallacious, deceptive, and simply plain opportunistic, which is the principle cause why, as a dietitian, I selected to write down this submit.
Everyone ought to pay attention to this form of factor. Oh, and in addition, this complement is NOT ‘backed by 3 clinical trials.’ Not even shut. See how MLM salespeople can principally say something to promote product?
Horrible. Also: a 30 day provide of GLP-X prices $75 USD. Not precisely what I’d name ‘affordable.’
Can we enhance our GLP-1 naturally utilizing meals and dietary supplements?
Let’s begin with the meals a part of the equation.
There are sure meals which might be recognized to extend ranges of GLP-1 in our our bodies. High-fibre grains, eggs, nuts, and avocado are amongst them, based on this 2016 evaluation.
In specific, mono and polyunsaturated fat, proteins, and fermentable fibre (fermentation within the intestine to short-chain fatty acids will increase GLP-1 ranges) from grains, legumes, and a few fruits like apples and inexperienced bananas. Research on this space is fairly hit and miss although, and as ordinary I’m reluctant to take animal research and extrapolate them to people.
It’s secure to say that even when we eat meals that enhance GLP-1 ranges in our our bodies, this doesn’t even strategy the effectiveness of GLP-1 agonists for weight reduction.
Let’s take into consideration this for a second – we’ve had entry to those meals ceaselessly. Would we impulsively uncover that they’ve these magical weight reduction powers past what we already know?
I extremely doubt it.
My suggestions listed here are the identical as all the time: numerous fibre, ample protein, wholesome fat. Can’t lose.
As far as dietary supplements, as with meals, there have been none which have proven the extent of effectiveness of GLP-1 agonist medicines.
If a complement does have related efficacy to precise GLP-1 agonist meds for weight reduction, it doubtless won’t be offered by a multi-level advertising and marketing firm. It can be regulated by the FDA and used as a official remedy.
What is Xyngular?
Xyngular is an MLM firm that sells diet merchandise.
I did an up to date Xyngular evaluation on my web site in 2020, and I doubt a lot has modified with the corporate since then.
Here’s a few of Xyngular’s product lineup. Typical fats burners, ‘craving controllers, and intestine well being boosters.
Most if not all diet MLM corporations make use of the identical methods to make gross sales (and that is on no account an exhaustive record):
Big claims which might be not possible to again up
Lack of oversight of their salespeoples’ social media posts
Poor or no analysis on their merchandise
Constant upsells
Taking benefit of girls who wish to make an earnings
I wrote about my points with MLMs and their coaches right here, however let’s simply say that Xyngular is unremarkable amongst its MLM friends.
What is Xyngular GLP-X?
Xyngular GLP-X is a complement that’s being marketed as an alternative choice to GLP-1 agonist medicines for weight reduction and ‘GLP-1 support.’ What is that, anyhow? I wasn’t conscious that our GLP-1 wanted to be supported.
Made up time period with obscure well being declare = pink flag.
It comes with all the ordinary bells and whistles of a newly launched MLM product – full courtroom press gross sales throughout social media by the Xyngular salespeople, cute little graphics that inform us principally nothing scientific, and naturally, magical and fantastical guarantees that this little bottle incorporates the reply to all of our issues…no prescription required!
Xyngular GLP-X components
Herbs and chromium and proprietary blends, oh my! Here’s what GLP-X has in it:
Carb administration mix
This proprietary mix incorporates Eriomin and berberine. This is the particular mix in Xyngular GLP-X that the corporate states will increase GLP-1.
Eriomin is a patented citrus bioflavonoid nutraceutical complement. A day by day dose (2 capsules) of GLP-X incorporates 250mg of Eriomin.
Where have I heard about Eriomin earlier than? Oh, proper! The Glucose Goddess’s subsequent complement, Anti-Spike, incorporates it as nicely. I wrote all about Anti-Spike right here, and simply to repeat what I mentioned about Eriomin in that case, there are two research about this citrus extract and blood glucose. Both are comparatively unremarkable when it comes to blood sugar discount.
One of the research, finished in 2019, noticed a 15% rise in GLP-1 with dosages of 200-800 mg of Eriomin over 12 weeks. However, researchers discovered it had no impact on physique weight, BMI, lean mass, fats mass, fats share, and hip waist ratio.
The 12-week 2022 research that includes Eriomin discovered a 17% rise in GLP-1 with 200 mg a day of the ingredient. However, physique weight and BMI remained unchanged.
You’ve in all probability heard me bang on and on in regards to the significance of ‘clinical relevance,’ and that is the right time to indicate you what I imply.
In the above research, we see that GLP-1 ranges have been certainly larger after supplementation with Eriomin. This sounds nice, till you’re wanting to make use of this ingredient to advertise weight reduction. Because regardless that there was a major change within the research topics’ GLP-1, nothing actually occurred to their weight whereas these ranges have been elevated.
It principally didn’t change a factor round weight.
Repeat after me: it could be ‘significant,’ however that doesn’t imply it’s clinically related to us!
As far as Berberine, we do know that it has constructive results for growing GLP-1 and for reducing blood glucose in folks with diabetes. However, berberine doesn’t decrease blood glucose by growing GLP-1 within the physique; it promotes insulin secretion and improves glucose regulation, amongst different mechanisms.
Again, medical relevance of this ingredient for GLP-1-related weight reduction? Probably none.
GLP-X additionally incorporates a proprietary ‘water balance blend,’ in any other case referred to as a diuretic. Peeing out fluids doesn’t equal ‘weight loss.’ Or, ought to I say, ‘fat loss.’
Then there’s the proprietary ‘appetite support blend,’ which incorporates the standard suspects: inexperienced espresso bean, 5-ATP, and phytosterols, none of which have ever been confirmed to facilitate vital weight reduction in people.
Even so, a ton of multi-level marketed merchandise proceed to place these components of their weight reduction merchandise. Unfortunately, science doesn’t care how exhausting you want for one thing to work so your product may be the ‘next best thing.’
A phrase about proprietary blends: I like to recommend not buying merchandise that comprise proprietary blends. These are principally smokescreens that corporations can conceal behind in order that they don’t need to reveal the precise quantities of components which might be of their merchandise. It could possibly be a little bit, it could possibly be lots. It could possibly be the efficient dose (assuming any of the components are efficient in any respect), it could possibly be much less. For GLP-X, for instance, we do not know how a lot Berberine or Eriomin is in every capsule. It’s a roulette wheel that I don’t suggest spinning together with your pockets or your well being.
GLP-X has two extra components which might be equally underwhelming for weight reduction and results on GLP-1: chromium and magnesium.
Nothing about these two minerals will increase weight reduction or GLP-1. That is all.
What? But I assumed GLP-X is ‘backed by 3 clinical trials’?
The undeniable fact that Xyngular and its salespeople can say that the components on this product are ‘clinically studied to increase GLP-1’ makes most individuals suppose that 1. GLP-X itself has constructive research behind it (it doesn’t) and a couple of. the components ship clinically related and significant outcomes for GLP-1 resulting in weight reduction.
Nope to all of that, however it’s a advertising and marketing tactic I see actually on daily basis with dietary supplements. It’s deceptive and it’s disappointing.
Does Xyngular GLP-X work?
While a number of the components in Xyngular GLP-X have been proven to enhance blood glucose administration in some folks, there isn’t a analysis to indicate that the GLP-X complement itself really does what Xyngular claims it does.
There are loads of GLP-X testimonials, however these are simply faked, and guess what? MLM coaches like to submit them, however conveniently neglect to submit the not-so-glowing opinions, too.
Why are we so determined to look a sure approach, that we belief our well being to those corporations and their salespeople, most of whom have zero related well being coaching and who don’t care about our well being, solely their gross sales? Please don’t.
As far as ‘natural’ GLP-1 dietary supplements, these are extra fable than reality. Just as a result of one thing will increase our GLP-1 ranges doesn’t imply that this results in the load loss results we’d see with GLP-1 agonist medicines. In reality, the analysis is fairly clear that in most (if not all) instances, it doesn’t.
Save your $75.