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For this research, researchers needed to research the connections between IBD, supplementing melatonin, and the next immune responses and bacterial compositions within the guts of mice. To achieve this, they created a mouse mannequin of IBD, administering melatonin to a portion of them.
Based on their evaluation, melatonin truly made signs and restoration worse for the mice who had been administered melatonin, displaying worsened intestine irritation, and through remission, slower restoration.
Namely, the mice who’d been administered melatonin confirmed notable indicators of colitis aggravation, delayed restoration, and elevated inflammatory markers, which the research authors say affirm the dangerous results of melatonin supplementation on a disrupted intestine barrier.
While these findings have but to be replicated in people, research co-author and immunologist Cristina Ribeiro de Barros Cardoso Ph.D. notes that individuals needs to be scrutinous in the case of hormonal dietary supplements.
“Our study shows that people should be careful about taking hormone supplements and that the ingestion of melatonin as a supplement can have adverse effects on health,” she says in a information launch, including, “[Melatonin is] a hormone and regulation of the interaction between all hormones and the immune system is very delicate.”