Homocysteine is an amino acid that is closely concerned in a organic course of known as methylation. During methylation, the bioactive type of folate (5-MTHF) donates a methyl group to homocysteine so it may be transformed into one other amino acid, methionine. When working optimally, methylation promotes cardiovascular, neurological, and reproductive well being; aids power manufacturing; bolsters cleansing pathways; helps longevity; and extra.
The downside is that greater than 50% of the U.S. inhabitants has a genetic mutation of the MTHFR gene that inhibits the physique’s skill to activate folate, so it cannot optimize methylation. If bioactive folate is not obtainable to assist convert homocysteine throughout the methylation cycle (i.e., as a consequence of an MTHFR gene variation or different causes—corresponding to poor eating regimen, hormone imbalances, stress, or publicity to toxins), homocysteine ranges can develop into too excessive.
Elevated homocysteine ranges are linked to the next threat of continual irritation, poor cleansing, heart problems, autoimmune situations, and sure—dementia.