From Dr. Joseph Mercola
Since COVID-19 first entered the scene, change of concepts has principally been outlawed. By sharing my views and people from varied consultants all through the pandemic on COVID remedies and the experimental COVID jabs, I turned a primary goal of the White House, the political institution and the worldwide cabal.
Propaganda and pervasive censorship have been deployed to grab management over each a part of your life, together with your well being, funds and meals provide. The main media are key gamers and have been instrumental in creating and fueling worry.
I’m republishing this text in its unique kind in an effort to see how the development unfolded.
Originally printed: April 25, 2020
Molecular hydrogen (H2 gasoline) has highly effective antioxidant and anti inflammatory results,1 as defined on this video by Tyler W. LeBaron, founding father of the science-based nonprofit Molecular Hydrogen Institute.
In his video, LeBaron opinions the pathophysiology of COVID-19 and explains why H2 is being clinically investigated by discussing the proposed mechanisms of how molecular hydrogen would possibly ameliorate illness.
In reality, a number of Chinese investigators are utilizing H2 remedy in COVID-19 sufferers,2,3 and preliminary outcomes4,5 are encouraging sufficient that Dr. Zhong Nanshan, the epidemiologist who found the SARS virus (SARS-CoV-1) in 2003, is now recommending H2 remedy for COVID-19.6
While extra analysis is required to verify advantages and helpful outcomes in COVID-19 instances, the most recent COVID-19 therapy information7 by the Chinese National Health Commission consists of hydrogen inhalation.
LeBaron features a video clip of Chinese sufferers given a hydrogen-oxygen inhaler combine, who say it eradicated chest ache and cough, and allowed for deeper respiration with out discomfort. That stated, LeBaron notes:
“There remains to be no clinically printed proof that H2 will really profit COVID-19 and this data is solely for academic functions. It doesn’t represent medical proof, and isn’t supposed to switch the steerage out of your well being care practitioner.”
Pathophysiology of COVID-19
As defined by LeBaron, the SARS-CoV-2 virus chargeable for COVID-19 enters the lungs, the place it assaults the kind 2 pneumocytes,8 alveolar cells chargeable for the secretion of surfactants that cut back the floor rigidity of fluids in your lungs and are thus vital for elasticity.
The SARS-CoV-2 virus makes use of a spiked protein to anchor itself to the ACE-2 receptor9 of the cell. This is the way it good points entry and releases its positive-sense single-strand RNA into the cell. By inserting its RNA, the virus primarily hijacks the cell, because it triggers viral replication to happen contained in the cell.
In response, macrophages (white blood cells) are activated to fight the an infection, and so they in flip launch a wide range of cytokines, together with interleukin-6 (Il-6), IL-1 and TNF-alpha, into your blood plasma. Once the cytokines enter your plasma, neutrophils are recruited, thus rising vasodilation (growth of your blood vessels) and capillary permeability.
Inside the cell, reactive oxygen species (ROS) are additionally created in an effort to kill the contaminated cell and forestall viral replication. This is an important a part of your physique’s protection system. However, as the method progresses you find yourself with rising quantities of ROS and irritation. Worse, because the virus continues to assault your kind 2 pneumocytes, your lungs can not work appropriately.
As the floor rigidity of the fluids in your lungs is decreased, your alveoli can now not keep the right gasoline change, and your oxygen requirement goes up. Declining elasticity of the lungs additionally makes respiration tougher. Add in excessive quantities of ROS, and the entire alveoli finally ends up dying. This is a part of what’s inflicting the cough.
As irritation and vasodilation progresses, you possibly can find yourself with low blood strain, which is why you are feeling fatigued and weak. Lower blood strain additionally causes low blood perfusion, which in flip means your cells won’t get the oxygen and vitamins they want for optimum perform. It additionally impairs metabolic waste elimination. The low oxygen ranges (hypoxia) end in feeling wanting breath.
Unless efficiently handled, this chain of occasions results in cell loss of life, multi-system organ failure (lungs, liver and kidneys), acute respiratory misery (ARD) and, in the end, loss of life.
Stopping the Destructive Cycle
To save the affected person, one thing must be completed to cease this harmful cascade of occasions. How will we inhibit viral replication and enhance immune system perform? As defined by LeBaron, many of the destruction happens by ROS and systemic irritation.
ROS are molecules that trigger oxidative injury. However, they are not all dangerous on a regular basis. Neutrophils that produce ROS additionally produce nitric oxide and superoxide, that are essential. Superoxide helps kill the pathogen, however you additionally don’t need an excessive amount of of it, so it must be regulated.
Nitric oxide additionally must be regulated. While it will probably inhibit viral replication and helps enhance your immune system, you do not need an excessive amount of. As ranges of superoxide and nitric oxide rise, they begin forming peroxynitrites, that are extraordinarily damaging, which in flip kind hydroxyl radicals, probably the most cytotoxic ROS.
Normally, when superoxide has completed its job, it is transformed by superoxide dismutase into hydrogen peroxide, which in flip is transformed into water and oxygen.
This course of is regulated by a transcription issue known as Nrf2/keap1. When this transcription issue is activated, it goes into the cell’s nucleus, the place it binds with the antioxidant response factor (ARE), which triggers your physique’s pure antioxidants comparable to glutathione and catalase.
As famous by LeBaron, Nrf2 — which is concerned in part 2 detoxing — regulates greater than 200 protecting proteins and enzymes. The drawback is that when ROS is overabundant and uncontrolled, the Nrf2 system is depleted and might now not regulate the inflammatory course of.
Understanding Molecular Hydrogen
Molecular hydrogen or H2 has the power to activate the Nrf2/keap1 pathway, thereby replenishing your endogenous antioxidants. In so doing, H2 helps regulate and keep homeostasis in the entire system, stopping the an infection from getting uncontrolled and inflicting cell loss of life.
Hydrogen also can downregulate NOX and NOS enzymes, thus decreasing superoxide and nitric oxide manufacturing respectively. This is sweet, as when these two molecules are elevated an excessive amount of they immediately mix to create the pernicious peroxynitrite molecule. H2 additionally helps your mitochondrial perform. Importantly, H2 selectively reduces peroxynitrites and hydroxyl radicals.
This offers H2 a big benefit over different antioxidants comparable to vitamin C, which act indiscriminately with superoxide and nitric oxide — each of which even have vital and helpful features. H2 doesn’t work together with both superoxide or nitric oxide. The solely factor H2 can react with are probably the most harmful ROS comparable to peroxynitrites and hydroxyl radicals.10
As a consequence, your superoxide and nitric oxide are left to carry out helpful features whereas the H2 eliminates probably the most harmful byproducts of superoxide and nitric oxide, whereas concurrently rising your physique’s pure manufacturing of antioxidants and regulating the enzymes that produce superoxide and nitric oxide. To get a clearer image in your thoughts of how H2 steps in to interrupt the harmful chain, see LeBaron’s video.
H2 additionally steps in to forestall a cytokine storm from occurring. A cytokine storm happens when the upregulation of cytokines is larger than your physique can deal with. Cytokines are regulated by transcription elements, and ROS regulate these transcription elements. Inflammatory transcription elements, in flip, create extra irritation, which stimulate extra ROS manufacturing.
This is a vicious cycle that leads to elevated cell loss of life, which results in multiorgan failure, which results in loss of life. H2 has been proven to control these transcription elements in a number of animal and human research, thus breaking the vicious cycle. This is what makes H2 so anti-inflammatory. As summarized by LeBaron on the finish of his video:
“Hydrogen gasoline, being a quite simple, small molecule, may help to control the redox standing of the cell by selectively decreasing the very dangerous [ROS], assist to control and enhance the Nrf2/keap1 pathway to take care of our physique’s redox homeostasis.
It additionally has regulatory results on irritation, to decrease persistent, dangerous systemic irritation by regulating every thing. Just reducing or inhibiting it [referring to ROS] will not be need we wish to do. We want all of this stuff.
This is in our immune system. We do not simply wish to eliminate it. Yes, it’s what’s killing us, however it’s also essential to have, in order that we will get higher. So, that’s the … rationale for [using hydrogen gas] for COVID-19.”
Dosing and Availability
Although the precise medical research on COVID-19 are being performed with H2 inhalation, H2 dissolved in water has been proven to be simpler than inhalation in different animal illness fashions.11 Additionally, one other article12 means that the H2-infused nitric oxide-producing beverage from H2Bev known as HydroShot, must also be clinically investigated for its reported preliminary results.
However, whereas there are numerous methods of getting H2, the only and most sensible supply system is molecular hydrogen tablets which might be dissolved in water. They are moveable and may be taken wherever, together with journey and on airways, and so they persistently present a excessive H2 focus. When utilizing the tablets it is vital to drink the water as quickly because the tablets are dissolved and the water remains to be “white,” because the H2 dissipates rapidly.
The molecular hydrogen tablets have the extra benefit of offering 80 mg of ionic elemental magnesium with every pill. Magnesium can function a pure calcium channel blocker to assist regulate excessive intracellular calcium ranges that may wreak havoc in your physique.
Also, absolutely the amount of H2 is way much less vital than pulsing or creating an acute elevation of H2 in your system over a brief interval. That acute elevation is what prompts the Nrf2 pathway. When publicity is steady, even when elevated, it has just about no impact.
Clearly, we’d like extra analysis to be higher capable of reply dosing questions, however within the interim, it appears customizing the dose to your private circumstances can be most applicable. So, in the event you’re in regular, non-stressful circumstances at dwelling, probably not doing something very traumatic and never exercising a lot, possibly taking H2 as soon as a day is enough.
However, in the event you train quite a bit, it’s possible you’ll wish to take it two to 3 occasions a day to assist cut back the oxidative stress out of your train. Ditto in the event you’re touring and exposing your self to free radical stress from ionizing radiation at 35,000 toes. In such a circumstance, it may be applicable to take it each two hours when you’re within the air.
Considering their security, ease of use, and helpful results on immune perform and well being, molecular hydrogen tablets are a no brainer answer for my part, and so they could possibly be fairly useful for a lot of situations, together with COVID-19, which is why H2 is being clinically investigated.