Blood Clots May Be the Root Cause of All Heart Disease

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Editor’s Note: This article is a reprint. It was initially revealed February 13, 2022.

In this interview, repeat visitor Dr. Malcolm Kendrick, a board-certified household doctor and creator of the e book, “The Clot Thickens: The Enduring Mystery of Heart Disease,” critiques the underlying mechanisms for coronary heart illness, which for the final century has been the main reason for demise within the U.S.

Of all of the books he is written, that is my favourite, because it goes into nice element, providing you with the organic understanding of the method of atherosclerosis resulting in coronary heart assaults and strokes. He additionally has stable methods for reducing your heart problems danger.

Incidentally, when you perceive the illness course of, then you can too perceive how each COVID-19 and the COVID jab can contribute to coronary heart illness. When requested why he is taken such an curiosity in coronary heart illness, Kendrick replies:

“When I used to be coaching as a scholar in medication, Scotland had the very best charge of coronary heart illness on the planet. Early on the reply for why was, ‘Oh, nicely, it is as a result of we’ve such horrible weight loss program, and we eat garbage meals like deep fried Mars bars.’

So, you eat an excessive amount of saturated fats, the saturated fats will get become ldl cholesterol in your bloodstream, after which it is absorbed into arteries and varieties narrowings and thickenings, which all sounds believable in the event you do not give it some thought too arduous.

But I additionally occur to go to France rather a lot, and what I seen about France was, they eat lots of saturated fats. They eat extra, in reality, than anybody else in Europe, and positively greater than Scotland. So, [this saturated fat] speculation definitely did not work for the French. They have the very best saturated fats consumption in Europe and lowest charge of coronary heart illness, and this has been the case for many years.

If you took all the danger components for France and Scotland [such as smoking, high blood pressure and diabetes], then the French had barely [higher risk], in response to typical considering. But, in reality, they’d one-fifth [the rate among age-matched men].

So, I believed, that is fascinating. It would not make a lot sense in response to what we’re instructed. Then whereas I used to be in medical faculty, a tutor in cardiology stated … LDL can not cross the endothelium. At the time, I did not know what LDL was, nor did I do know what the endothelium was, however it sounded vital.

She had been taking a look at coronary heart illness as a distinct course of for many years … So, I believe that is actually the place I acquired began. Once you begin questioning what the issue is, you find yourself questioning increasingly more and also you begin considering, gosh, that is simply nonsense, is not it? This complete speculation is simply nonsense. So, I began selecting it aside.”

The Thrombogenic Hypothesis

“The Clot Thickens” is Kendrick’s effort to elucidate another speculation for what truly causes coronary heart illness. If it is not saturated fats and ldl cholesterol, what’s it? In 1852, a Viennese researcher, Karl von Rokitansky, developed what he referred to as the encrustation speculation of coronary heart illness.

Today, this speculation has been renamed the thrombogenic speculation. “Thrombo” stands for thrombosis, i.e., blood clots, and “genesis” means the reason for, or the beginning of. So, the thrombogenic speculation is that blood clots are the fundamental pathology that causes all coronary heart illness.

In a nutshell, when a blood clot varieties in your artery wall, which might occur for various causes, it would sometimes be coated over and dissolved. An issue arises, nevertheless, if the blood clot is just not absolutely eradicated and one other blood clot varieties in the identical “susceptible” space. This then turns into what’s conventionally known as atherosclerotic plaque.

“The atherosclerotic plaque is mainly a buildup of blood clot, restore, blood clot, restore, blood clot, restore,” Kendrick explains. “If the blood clotting course of is quicker than the restore course of, you might have a plaque that regularly grows and ultimately thickens the artery wall till it narrows sufficiently that the ultimate blood clot, on prime of the prevailing plaque, is the factor that may trigger a coronary heart assault or stroke …

If you narrow by the plaque and have a look at it, it nearly appears to be like like tree rings. You can see there’s been a clot, restore, clot, restore, clot, restore, clock, restore over time.

It’s broadly accepted {that a} blood clot forming on an present plaque will trigger the plaque to develop in measurement. You can discover 10,000 papers saying that that is the case. What the mainstream will not settle for is {that a} blood clot on a wholesome artery wall can provoke the entire course of.

So, to an extent, all I’m saying to individuals is, nicely, we all know blood clots trigger the ultimate occasion. We know blood clots trigger plaques to develop. Why will not you settle for that blood clots are the factor that begins it within the first place? Because then we’ve one course of all over, and it is smart, as a result of it suits with what you may see.”

As famous by Kendrick, the standard view is that low-density lipoprotein or LDL will get into the artery wall the place it initiates plaque formation. It then, inexplicably, stops initiating plaque, and the plaque continues to develop by the addition of repeated clots.

However, Kendrick says, when you begin drilling down into the ldl cholesterol, aka LDL speculation, the entire thing begins to disintegrate. LDL merely can not clarify the illness development. Yet regardless of the various holes within the principle, the concept LDL causes coronary heart illness is touted as an absolute, proven fact.

What’s the Mechanism?

In order to justify a speculation, you must have a mechanism of motion. Once you perceive the mechanism of the particular illness course of, then you may put the puzzle items collectively. Kendrick begins his rationalization:

“Your blood vessels are lined with endothelial cells, a bit like tiles on a wall. Endothelial cells are additionally coated themselves in a factor referred to as glycocalyx. If you attempt to choose up a fish, it will slip by your fingers; it is very slippery. The purpose it is slippery is as a result of it is coated in glycocalyx and the glycocalyx is extremely slippery. It’s nature’s Teflon.

So mainly, in our case, the glycocalyx [is inside] our blood vessels, to permit the blood to journey by with out it sticking, with out harm occurring. So, you might have this sort of damage-repellent layer on prime of your endothelial cells.

Now, if that layer is broken, after which the endothelial cell itself beneath is broken, then the physique will say, ‘Oh, we have got harm to a blood vessel, we should have a blood clot there as a result of we might bleed out.’ So, a blood clot varieties on the realm of injury, and instantly stops [the bleeding].”

The blood clot would not simply carry on rising and rising. If it did, you’d die anytime you had a blood clot. Instead, when a clot varieties, different processes step in to stop it getting too massive, which is why each blood clot would not trigger a stroke or coronary heart assault. Once the clot has stabilized, and has been shaved down, the realm is roofed over by endothelial progenitor cells, made within the bone marrow, that float round in your blood stream.

When a progenitor cell finds an space that has been broken, it attaches itself to that space, together with others, forming a brand new endothelial layer. The remaining blood clot is now mendacity “inside” the artery wall itself. So, mainly, it is the restore course of that may result in plaque buildup throughout the artery wall. In time, if harm outstrips restore, this could slim the artery and scale back blood stream.

What Damages Endothelial Cells?

The query is, what can harm the endothelium within the first place? Here, Kendrick makes use of the SARS-CoV-2 mechanism for instance:

“The COVID virus enters endothelial cells by the ACE2 receptor. It prefers endothelial cells as a result of they have ACE2 receptors on them. It will get into the endothelial cell and begins replicating, then bursts out, damaging the cell. Bingo, you’ve got acquired an space of injury.

Of course, added to this, when cells have viruses inside them, they ship out misery indicators to the immune system saying, ‘I’ve been contaminated, come and kill me,’ and so the immune system begins to have a go on the endothelial cells. This is why you may get an issue, as a result of the endothelial cells are being broken and stripped off.

Blood clotting happens on the factors of injury and hey, presto, you are having clotting, you are having strokes, you are having coronary heart assaults, which is the factor that folks at first could not perceive [about COVID-19]. Yet it is very clear that what’s taking place is you’ve got acquired harm to the endothelial cells.

Obviously, you and I each know that in the event you get a [COVID jab], the cells are triggered to supply the spike protein, and these cells are sending out misery messages saying, ‘I’m contaminated.’ You must be very cautious if you wish to stick one thing into cells that then says to the immune system, ‘Please come and destroy me,’ as a result of that is what the immune system goes to do.

But shifting on from that, what different factor may cause endothelial harm? The reply is issues like smoking. Smoke particles get out of your lungs, they go into your blood vessels and so they trigger harm … You smoke one cigarette and an entire bunch of microparticles seem in your bloodstream, which suggests endothelial cells are dying.

Luckily as endothelial cells die, one other message is distributed to the bone marrow saying, we’d like extra endothelial cells and it stimulates endothelial progenitor cell manufacturing. These endothelial progenitor cells rush round protecting over the areas of injury.

Some people who smoke have sufficient restore occurring and if you’re youthful, it is okay. As you grow old and your restore programs start to fail a bit, cigarette smoking turns into increasingly more of an issue.”

Other issues that may trigger endothelial harm embody:

Repairing the Glycocalyx

As defined by Kendrick, the glycocalyx layer resembles a garden, with slippery filaments that stick up. Within this glycocalyx layer you might have nitric oxide synthase (NOS), which produces nitric oxide (NO), and you’ve got NO itself, in addition to various different anticoagulant proteins. The glycocalyx is definitely a potent anticoagulant layer, so it stops blood clots forming. If glycocalyx is broken, your danger of blood clotting will increase.

“It’s a really difficult layer,” Kendrick says. “It’s like a jungle stuffed with issues that say, ‘Don’t stick with this, avoid this.'” Within it, you even have albumin, protein complicated produced by the liver. Albumin comprises the proteins that assist keep and restore the glycocalyx. A reality that the majority medical doctors are unaware of is that, if in case you have a low albumin stage, you are considerably extra prone to die of coronary heart illness.

The excellent news is that whereas the glycocalyx layer will be quickly destroyed, it will also be quickly repaired. (Experiments have proven that in an space the place the glycocalyx has been fully stripped off, it may be fully repaired in a single second.) Supplements like chondroitin sulfate and methylsulfonylmethane (MSM) will be useful on this regard.

“If you try to clarify that by the LDL mechanism, it simply would not work,” Kendrick says. “They have found that in the event you give chondroitin sulfate as a complement — which usually is for arthritis and stuff like that — it reduces the danger of coronary heart illness fairly significantly. How do you clarify that? Well, you may clarify that since you’re defending your glycocalyx.

These are the type of issues that make no sense in the event you like trying on the typical concepts of coronary heart illness, however are instantly and simply defined in the event you say, ‘We must preserve our glycocalyx wholesome and we’ve to maintain our endothelial cells beneath them wholesome.’

Otherwise they are going to be broken and stripped off, after which we’ll get a blood clot, and if we preserve getting blood clots at that time, we’ll find yourself with a plaque and ultimately one of many blood clots on that plaque will kill you from a coronary heart assault or a stroke.”

Blood Flow Restriction Training

A way of life technique that may assist restore endothelial harm is blood stream restriction (BFR) coaching. In response to BFR, your physique produces vascular endothelial development issue (VEGF), which acts as “fertilizer” for the endothelium. You can study the ins and outs of BFR in my free BFR report. VEGF additionally induces the synthesis of nitric oxide (NO), a potent vasodilator, and it stimulates endothelial progenitor cells.

“NO protects the endothelium. It is anticoagulant — essentially the most potent anticoagulant we’ve within the physique. It’s actually the magic molecule for cardiovascular well being,” Kendrick says.

“At one time NO was referred to as Endothelial Derived Relaxation Factor (EDRF) NO was one thing nobody believed might probably exist within the human physique. NO is definitely a free radical. Everyone says free radicals are terribly damaging and unhealthy.

To that I reply, ‘Well, you might want to know that the chemical that’s the single most vital protecting chemical within the physique for the cardiovascular system is an extremely free radical referred to as nitric oxide.'”

Some anticancer medicine are designed to dam VEGF, because the tumor wants angiogenesis — which is the creation of latest blood vessels which can be required to offer adequate “vitamins” Without these new blood vessels, the tumor dies off. Unfortunately, in the event you block VEGF, you additionally block NO, which then raises your danger for coronary heart illness.

“These medicine had been nearly faraway from the market,” Kendrick says, “as a result of regardless of their anticancer exercise, they had been procardiovascular illness to fairly a scary diploma.

[That’s why], if you’re given bevacizumab or Avastin as an anticancer drug, they now provide you with angiotensin changing enzyme inhibitors (ACE inhibitors), that are blood stress reducing tablets, and ACE inhibitors have a selected influence on bradykinin, which will increase NO synthesis.”

Strategies to Lower Your Thrombotic Risk

In his e book, “The Clot Thickens: The Enduring Mystery of Heart Disease,” Kendrick critiques many various methods that may decrease your illness danger. Here’s a short-list of examples coated in far better depth within the e book, in addition to a few of my very own suggestions that I carry up within the interview: